Table 2 Adverse reactions to subcutaneous immunotherapy in different cluster studies
Reference | Study characteristics | Build-up phase No adverse reactions | First year of the maintenance phase No adverse reactions | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Local reaction | Systemic reaction | Local reaction | Systemic reaction | ||||||||||||||
n | Age mean (95% confidence interval) | Allergen | No injections and visits | Build-up duration (weeks) | E | D | Total | E | D | Total | E | D | Total | E | D | Total | |
Solá, 2018 | 110 | 31 (95% CI 28–34) | Grass pollen and/or Olea europaea | 2/2/2 | 2 | 3 | 50 | 53 | 2 | 6 | 8 | 0 | 7 | 7 | 0 | 1 | 1 |
Walker, 2001 [7] | 22 | 32 (95% CI 22–64) | Grass pollen | 3/2/2/1/1/1/1 | 4 | 0 | 0 | 0 | 0 | 4 | 4 | 0 | 0 | 0 | – | – | 3 |
Crimi, 2004 [9] | 15 | 32 (95% CI 21–54) | Parietaria | 2/2/2/2/1/1/1/1 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 3 | 0 | 0 | 0 |
Nanda, 2004 [10] | 20 | > 18 | Cat hair and dander | 2/2/2/2/1 | 5 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Tabar, 2005 [11] | 120 | 19 (SD9.8) | Dermatophagoides pteronyssinus | 4/3/2/2/2/2/1 | 6 | 6 | 0 | 6 | 1 | 3 | 4 | – | – | 1 | – | – | 4 |
Colás, 2006 [13] | 41 | 34 (95% CI 18–51) | Salsola kali | 3/3/1 | 2 | 16 | 0 | 16 | 4 | 12 | 16 | 0 | 0 | 0 | 0 | 0 | 0 |
Subiza, 2008 [14] | 22 | 30 (95% CI 12–60) | D. glomerata, T. Paniceum | 2/2/1 | 2 | 0 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Zhang, 2009 [16] | 45 | 25 (95% CI 15–36) | Dermatophagoides pteronyssinus | 3/2/2/2/2/2/1 | 6 | 11 | 0 | 11 | 5 | 0 | 5 | – | – | 7 | – | – | 6 |
Lou, 2012 [17] | 25 | 12 (95% CI 9–13) | Dermatophagoides pteronyssinus | 3/2/2/2/2/2/1 | 6 | – | – | – | – | – | – | – | – | – | – | – | – |
Klimek, 2014 [18] | 61 | 37 (SD 10.4) | Grass and rye pollen | 2/2/1 | 5 | 7 | 0 | 7 | 2 | 3 | 5 | – | – | – | – | – | – |
González-Gutiérrez, 2012 [6] | 127 | 28 (SD 11.8) | Grass pollen | 2/2/2/1 | 4 | 8 | 24 | 32 | 3 | 11 | 14 | – | – | – | – | – | – |
177 | 30 (SD 12.3) | Grass pollen | 2/2/1 | 4 | 4 | 22 | 26 | 5 | 15 | 20 | – | – | – | – | – | – | |